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These include COPD, 46 cystic fibrosis, 47 , 48 influenza infection, 49 and alcoholism, 50 , 51 as ethanol impairs Th1/Th2 balance via GSH depletion 52 (Table 3)

DM might facilitate the development of AD through an increase in the level of oxidative stress and advanced glycation end products (AGEs), which causes structural and functional abnormalities in the brain (Gispen and Biessels, 2000

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