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reported that patients with ovarian cancer, who are carriers of glutathione-S-transferase class ( GSTM1)-null genotype or carriers of non- GSTM1-wt/GSTT1-wt genotypes, when treated with both paclitaxel and cisplatin, present higher mean survival time [59], suggesting a role for GSH in paclitaxel resistance also

Elevated glucose flux increases mitochondrial electron pressure, driving excess superoxide generation

doi: 10.1186/s12995-017-0161-x 99

Parkin and PINK1 mitigate STING-induced inflammation

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Elevated IOP, primarily caused by partial or complete obstruction of the aqueous humor outflow, is a key pathological risk factor in glaucoma