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The accumulation of free cholesterol in LSEC endolysosomes disrupted Rab7 membrane trafficking and impaired the transport of TLR9 from late endosomes to lysosomes, enhancing activation of the TLR9/inflammasome pathway mediating APAP-induced liver injury

The increase in glycolysis in these cells is substantially rerouted toward the PPP by downregulating the inhibitory sedoheptulose kinase CARKL

Ding CF, Chen WQ, Zhu YT, Bo YL, Hu HM, Zheng RH

Authors have also evaluated that 1, 8-cineole (Eucalyptol) also improved the epithelial barrier disruption and pathological symptoms in DSS induced mice [118]

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