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Kidney Int Rep

FIGURE 9 4 Discussion GHK and its bioactive form, GHK-Cu, have been demonstrated to be safe and effective in various cellular, tissue, and animal models ( In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses ( in vivo and in vitro experimental models revealed that GHK-Cu upregulates the expression level of Occludin and ZO-1, suggesting its potential role in promoting intestinal barrier repair

When there is naturally enough glutathione in the cells, it offers itself up to free radicals, so they dont try to attach to other cells and cause damage

We will not address this question further in this paper, as peer reviewed papers on that topic are lacking

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doi: 10.1096/fj.04-3486fje, 54 IsookaN.MiyazakiI.KikuokaR.WadaK.NakayamaE.ShinK.et al