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Directing evolution: the next revolution in drug discovery

doi: 10.3390/ijms22126222

a NNMT inhibitor such as a cation of Formula I or IA, or otherwise disclosed herein chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy

Rather than forcing cells to behave differently, it upregulates the growth factors and signaling pathways that are already part of the natural healing cascade VEGF for blood vessel formation, ERK1/2 for cell proliferation, and collagen deposition pathways for structural repair

But he wasnt a hothead