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Later studies, combining purified human proteins or human liver microsomes with specific inhibitors confirm the role of CYP2E1 in bioactivation of toxic levels of APAP, but also report involvement of CYP2A6 [31,32]

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A dedicated cardiovascular outcomes trial (CVOT) for orforglipron has not been mandated by the FDA for initial approval but may be required or conducted voluntarily as a post-marketing commitment, following the precedent set by the SELECT trial for semaglutide