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Growth hormone secretagogues: structure, function, and mechanism of action. Endocrine Reviews

doi: 10.1038/nature09448 Morales, Rodrigo A

Cell 188 , 45674585 (2025)

While MS was initially suspected, given the history of optic neuritis and paresthesia, this diagnosis was ruled out on the basis of normal MRI findings and the absence of spinal cord involvement or demyelinating lesions

Consequently, additional medicinal chemistry-based optimization of the structure will be needed to improve its pharmacodynamic and pharmacokinetic properties before efficacy studies of this scaffold in mouse models of infection can be undertaken