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Notably, it is not accredited for medical use but is studied for experimental functions

Settembre et al., 2012), a master transcription factor coordinating lysosomal biogenesis and autophagic gene expression

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Tumor-intrinsic pathways include enhanced DNA repair, apoptosis evasion, metabolic reprogramming, and transcriptional or epigenetic plasticity, while tumor microenvironmental influences such as hypoxia, immune suppression, and stromal remodeling further sustain resistant phenotypes

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