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Safety and Tolerability: Where They Diverge Both compounds share the tolerability profile typical of appetite-suppressing metabolic peptides, but retatrutide carries additional signals that trace directly to its glucagon arm

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Finally, more translational work is needed to determine whether AX can provide clinical benefits in conditions characterized by metabolic dysfunction and chronic low-grade inflammation, such as obesity, type 2 diabetes, or impaired muscle regeneration

Kirkland RA, Franklin JL