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Diabetic peripheral neuropathy (DPN) Despite advances in clinical care, DPN remains a prevalent complication of diabetes, with a lifetime incidence exceeding 50%

Genomics 130 WangF.WangC.LiuP.LeiC.HaoW.GaoY.et al (2016)

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However, consumption of dietary AGEs from sources such as fructose- or sucrose-enriched diets and/or soft drinks can worsen liver fibrosis faster than consumption of endogenous AGEs

Whether alterations in metabolism drive secondary injury processes or simply result from the subsequent depletion of cellular energy stores and oxidative stress is less clear