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BioMed Pharmacother (2022) 148:112765

[3] The lipoyl domain itself is attached by a flexible linker to the E2 core and the number of lipoyl domains varies from one to three for a given organism

Interestingly, preclinical models have shown that curcumin can decrease the expression of Th1 cytokines (IL-12, IFN-gamma, TNF-alpha, IL-1) and increase the expression of Th2 cytokines (IL-4 and IL-10) in colon mucosa, promoting a shift from Th1 to Th2 [510]

Arch Intern Med 171(6):507515 Li C, Ford ES, Zhao G, Balluz LS, Giles WH, Liu S (2011b) Serum -carotene concentrations and risk of death among US adults: The third national health and nutrition examination survey follow-up study

Student t test was conducted for intergroup comparison

Therefore, UA may not only directly reduce oxidative damage, but also improve the clearance of A by inducing autophagy, thus exerting neuroprotective effects