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The good news is that glutathiones melanin-inhibiting action can, in theory, help reduce hyperpigmentation regardless of the cause

Yan L-J, Allen D (2021) Cadmium-induced kidney injury: oxidative damage as a unifying mechanism

10.1016/j.jcf.2019.02.010 86 HenkeM

This is mainly through the adrenal glands producing stress hormones such as cortisol

doi: 10.14670/HH-18-421 163

222 In one randomized placebo-controlled trial, 120 nondiabetic men and women aged 1870 years with stage 34 CKD and low ( 50 year) outcomes after kidney donation compared to well-matched healthy controls