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Acknowledgements This work was supported by NIHR01HL160014 (to M.U.-F.), R01HL174014 (to T.F., M.U-F., V.S.), R01HL147550 (to T.F., M.U.-F.), P01HL160557 (to T.F., M.U-F), VA Merit Review grant I01BX001232 (to T.F.), AHA22TPA971863 (to T.F.)

Although we performed multivariate adjust- ments, residual confounding may persist due to unmea- sured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortied products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to inuence homocysteine metabolism and folate cycling, thereby potentially altering the func- tional demand for vitamin B12

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[139] This could be associated with loss of blood during menstruation, or with pregnancy

Both supplements contain L-Ergothioneine, but Mega L-Ergothioneine delivers a higher 25 mg dose, ideal for adults seeking enhanced support for normal cellular function

participation was 24 weeks [IQR 12-42]