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Since the accumulation of uremic toxins in CKD patients engenders various neurological complications, treatments that target the significant reduction of these metabolites not only significantly delay CKD progression but also greatly improve cognitive function in these patients (Faucher et al., 2023)

For each iteration, we regenerated a new model based on the gene expression and a partial set of the metabolite uptake and secretion rates and used these models to predict the flux rate through the reaction whose flux measurement was omitted

Deficiencies in zinc have been observed in some women with PCOS, and it has been hypothesized that this may contribute to the insulin-resistant phenotype of the condition

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Timmerman et al (45) identified a subtype of TNBC by evaluating the functional metabolic profiles of breast cell lines, which demonstrated that xCT expression levels are upregulated in one-third of TNBC cases

Nat Rev Drug Discov 18(4):295317