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Activating the HGF/c-Met signaling pathway potentiated the expression of nerve growth factor (NGF) to recruit nerves and promote the PNI

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In summary, plant-derived bioactive compoundsespecially those targeting autophagyhave shown promising clinical results against MAFLD and represent valuable candidates for future drug development

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Clinical studies and meta-analyses suggest that ALA supplementation can lead to small but meaningful improvements in fasting glucose and insulin sensitivity, particularly in people with type 2 diabetes or metabolic syndrome.2 24 That said, these effects are generally modest and ALA should never be viewed as a substitute for prescribed diabetes medications

It has also been demonstrated that reduced epidermal thickness, cell damage, impaired barrier function and altered surface characteristics were found in human organ-skin models constructed with premature senescent fibroblasts (80)