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0.08 M MnCl 2 ) and vitamins (0.1 mg/l cyanocobalamin, 0.08 mg/l 4-aminobenzoic acid, 0.02 mg/l D-(+)-biotin, 0.2 mg/l niacin, 0.1 mg/l Ca-D-(+)-pantothenic acid, 0.3 mg/l pyridoxamine-chloride, 0.2 mg/l thiamindichloride) at 37 C

Hydrogen sulfide (H 2 S), a gaseous signaling molecule produced by some cells within the body, acts as a vasodilator (relaxes blood vessels) and thus may have cardioprotective properties (51, 52)

F., Beuerman, R

To avoid immune rejection to the allogenic islets, they design an effective immunosuppressive regimen including sirolimus, low dosage of tacrolimus, and daclizumab against IL-2 receptors instead of traditional glucocorticoid (5)

Taken together, this study provides immunogenicity assessment which is closely implicated with toxicokinetic study of GX-G3 in 4-week repeated administrated toxicological studies