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doi: 10.1038/s41419-021-03813-6 149 HuangJKuangWZhouZ

Other Names for This Condition Hyperammonemia, type III N-acetylglutamate synthetase deficiency NAGS deficiency Additional Information & Resources Genetic Testing Information Genetic and Rare Diseases Information Center Patient Support and Advocacy Resources Clinical Trials Catalog of Genes and Diseases from OMIM Scientific Articles on PubMed References Caldovic L, Morizono H, Panglao MG, Cheng SF, Packman S, Tuchman M

61,62 The acetylation of p53 at certain sites hinders the phosphorylation of several serines located in the p53 NTD, which activates genes with high p53 affinity, including CDKN1A

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PMID: 38641160 Sci Rep 2025 Oct 16;15(1):36227

Although we could not give a definitive answer to that because there was no statistically significant AE differences between group 1 and group 2, group 1 showed a numerical trend towards fewer TEAEs, fewer dropout rates due to AEs, and fewer moderate to severe AEs, suggesting that 15 mg/day dose-titration might be preferable than alternate dose titration (group 2)