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While canonical motifs exist in unmodified protein sequences, post-translational modifications such as ubiquitination, acetylation and phosphorylation can create equivalent targeting sequences, thereby enhancing the diversity of CMA substrate proteins (39)

Therefore, targeting cellular oxidative stress through antioxidants has been suggested as a potential therapeutic option against neurological disorders, particularly using natural plant extracts

We synthesized PEIconjugated R 8 A(2535) and tested its therapeutic effect in the APP/PS1 transgenic mice via intranasal administration

doi: 10.1016/0146-5724(80)90190-9

X.PatelS.JonesH

As for now, adhere to my motto: TEST DON'T GUESS