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Figure 8 According to Peng et al., sophoridine could mediate the MAPK signaling pathway, enhance the expression of estrogen-related receptor gamma (ESRRG) to promote -catenin degradation, and inhibit the repair of double-stranded DNA breaks to caused cell cycle arrest at the G2/M phase, thereby lowering GC cell survival and increasing the efficiency of cisplatin

A key study by Simon et al

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PizzutiDSenzoloMBudaAChiarelliSGiacomelliLMazzonEet al

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Occurrence of psychotropic pharmaceuticals in surface waters is the reason for their presence in tissues of aquatic organisms (Brooks et al