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The confidence is remarkable given the near-total absence of clinical evidence behind most of it

The content of GSH and nicotinamide adenine dinucleotide phosphate (NADPH) directly affects the GPX4 activity [22]

doi:10.1177/03635465251357593

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PubMed searches return zero combined trials as of early 2026

GSTO1 knockdown as well as the small-molecule GSTO1 inhibitor C1-27 also caused downregulation of the Wnt inhibitor Dickkopf 1 ( DKK1 ), thombospondin 1 ( THBS1 ), the cysteine-rich angiogenic inducer CYR61 and caveolae scaffolding proteins CAV1 and CAV2 , among others