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Pirzada OM, McGaw J, Taylor CJ, Everard ML

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Fascinating clinical research on a genetic form of autonomic dysfunction, Familial Dysautonomia, revealed that tocotrienols actively induce the expression of the IKBKAP gene, reversing specific protein deficiencies and drastically reducing the frequency of autonomic crises

[] These findings suggest that SMYD1 regulates PGC-1 expression to maintain mitochondrial function and cardiac bioenergetics by modulating H3K4me3 marks on its promoter

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[DOI] [PubMed] [Google Scholar] 9.Shui Y.B., Holekamp N.M., Kramer B.C., Crowley J.R., Wilkins M.A., Chu F., Malone P.E., Mangers S.J., Hou J.H., Siegfried C.J., et al