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Characterization of PANoptosis-related genes in Crohns disease by integrated bioinformatics, machine learning and experiments

This upregulation leads to an increased expression of lipogenic genes, including sterol regulatory element-binding proteins (SREBP1c) and diacylglycerol acyltransferase-2 (DGAT2), which suggests that miR-370 provides a further point of regulation of this pathway 86

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Additionally, NCOA4-ferritin heavy polypeptide 1-mediated iron metabolism disorder is related to retinal ganglion cell ferroptosis following pathologically high intraocular pressure injury [37]

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In addition, ABCG2 rs2231142 considered a risk allele for gout ( PDZK1 Polyvalent PDZ domain 1 (PDZK1) is a multi-domain protein containing four PDZ domain tubular cells observed in the apical membrane of the kidney proximal tubule