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Selenoprotein P, synthesized in enterocytes and the liver, contains 10 selenocysteine residues [88] and enables the distribution of this element to peripheral tissues via endocytic receptors, including apoer2 and megalin [89]

PMID: 69 HerxheimerAPetrieKJ

despite only modest gains in intrinsic potency, it achieves effective concentrations in vivo and delays tumor growth in xenograft models (12)

Together with the spread of -synuclein, two key processes that may contribute to cognitive decline in PD are tau accumulation and neuroinflammation [225]