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However, a common denominator of this complex mechanism is the generation of ROS, which are responsible for the increased expression of protooncogenes and the silencing of tumor suppressor genes

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Genome-scale metabolic model of Helicobacter pylori 26695

These discrepancies may arise from different experimental conditions, highlighting the sensitivity of macrophages to material stiffness and the need for further studies to fully understand the role of matrix stiffness on macrophage phenotype commitment