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RothEMGoldbergACCatapanoALTorriAYancopoulosGDStahlNet alAntidrug antibodies in patients treated with alirocumab

In contrast, EGCG-specific pharmacological pathways were almost entirely metabolic signaling pathways, including steroid biosynthesis, glycerophospholipid metabolism, fat digestion and absorption, ether lipid metabolism, FoxO signaling, mTOR signaling, insulin secretion, and estrogen signaling

All the experiments were performed according to ethical guidelines

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PCA analysis based on the metabolomic state revealed distinct clustering of the two cohorts, suggesting a distinct metabolic BM microenvironment in LTR compared to STR (Fig