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PDE4 inhibitors Phosphodiesterase 4 (PDE4) can hydrolyze cyclic adenosine monophosphate (cAMP) and plays an important role in many biological processes

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doi:10.1152/physiolgenomics.00064.2001 Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM (2013) miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease