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Birth Defects Res C Embryo Today

and "History of EOP"

The clinical response to B12 treatment in SCD patients is expected to be better when large doses of B12 are administered more frequently than when B12 is administered less frequently [96]

The essential amino acid tryptophan also depends on B6 for its utilization

This leads to the development of hypoxia (decreased oxygen levels) in intestinal epithelial cells and activation of hypoxia-inducible factor alpha (HIF-1) (Wu et al., 2020)