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Aldehyde dehydrogenase then oxidizes - N -trimethylaminobutyraldehyde to - N -trimethylaminobutyrate with NAD + as a cofactor

Further reagents used are listed in the Supplementary Information

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Curcumin at low doses potentiates and at high doses inhibits ABT-737-induced platelet apoptosis

The principle of the assay resembles that of affinity purification of proteins in biochemistry: metals binding to the ligand on the beads and the rest in the buffer are separated by a spin-column and quantified by ICP-OES