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Subsequent analyses were performed using residual plasma samples from 19 of these 20 subjects

Giurato G, Terenzi I, Chiuso F, Salvati A, Rizzo F, Tarallo R, Weisz A, Nassa G

Moreover, high doses of L-Arg can induce the expression of arginases, which metabolizes L-Arg, and increase arginase activity is associated with eNOS uncoupling and endothelial dysfunction [122, 226, 227]

Chen R., Sun S., Wang C., et al

Primary defects in genes that encode mitochondrial proteins and/or metabolic substrates and enzymes can increase neuronal and glial network excitability

Institutional Review Board Statement All animal manipulations were made in accordance with the EU Directive 2010/63/EU for animal experiments