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3 Ferroptosis: a novel player in depression pathogenesis Dixon and his team introduced the concept of ferroptosis in 2012, characterizing it as an iron-dependent mode of programmed cell death marked by the build-up of lipid hydroperoxides (Dixon et al., 2012)

This table systematically maps the major pathways disrupted in adipocyte dysfunction, tracking changes from molecular mechanisms to systemic consequences

J.BarrientosT.et al (2015)