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[DOI] [PubMed] [Google Scholar] 31.Sambon M., Wins P., Bettendorff L

Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)

4 Evidence suggests that frataxin deficiency inhibits mitochondrial respiration and promotes production of reactive oxygen species (ROS), causing mitochondrial dysfunction, oxidative stress and subsequent mitochondrial iron accumulation

10.1080/19490976.2021.1994833 146 ZhongH.ZhangH.HuY.HeS.QuH.HeJ.et al (2023)

And I think that we're only learning now this interplay

), loading agents: tricalcium phosphate - microcrystalline cellulose, vitamin C, pine extract (Pinus pinaster), zinc bisglycinate, anti-caking agent: magnesium salts of fatty acids, vitamin B3, L-selenomethionine (dicalcium phosphate), vitamin B2 Take one tablet daily preferably in the morning before breakfast