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Independent replication by groups not affiliated with the original researchers is limited

Effects of a long-term lifestyle modification programme on peripheral neuropathy in overweight or obese adults with type 2 diabetes: the Look AHEAD study

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Furthermore, activation of other signaling molecules such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kB), apoptosis signal-regulating kinase 1 (ASK1), and c-Jun N-terminal kinases (JNK)/P38 may lead to mitochondria-dependent apoptosis (Kong et al., 2019)

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