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10.1038/nature12111 Huo, J., Yu, Q., Zhang, Y., Liu, K., Hsiao, C.D., Jiang, Z., et al., 2019

Together, they provide a powerful defense against pathogens and support the body's natural immune response

Huang, T., Fang, L., He, R., Weng, H., Chen, X., Ye, Q., et al

doi: 10.1111/pcmr.12684 142 KimNHChoiSHLeeTRLeeCHLeeAY

Since both accumulation and complete elimination of BACE1/A adversely affect recovery after SCI, biological regulation of A or BACE1 levels after SCI by modulation of components of the UPS such as Fbx2-Uch-L1 via peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1alpha or gene expression (Gong et al., 2010, 2013b) may be a feasible strategy for the SCI treatment and AD (Figure 3)