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2.3 Bone marrow-derived macrophage (BMDM) isolation and culture BMDMs were derived from the bone marrow, which was isolated from male C57Bl/6 mice and cultured in DMEM (HyClone) supplemented with 1% penicillin/streptomycin (Invitrogen), 10 ng/mL M-CSF (Peprotech) and 10% FBS (Invitrogen)

V.BellK.TullyT.FangY.SehgalA.et al (2008)

2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis

Betaine is utilised in most tissues as an osmoproctectant in addition to its primary role as a methyl group donor in liver metabolism (reviewed by Zhao et al, 2018)

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Bridging size and charge effects of mesoporous silica nanoparticles for crossing the bloodbrain barrier