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Tirzepatides co-agonist activity leads to superior glucose-lowering and weight-loss effects compared to GLP-1 receptor agonists alone Muller, Nature Reviews Drug Discovery Originally developed by Eli Lilly and marketed under the brand name Mounjaro , tirzepatide was first approved by the FDA in 2022 for type 2 diabetes

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The tirzepatide vs semaglutide side effects comparison shows tirzepatide generally has a comparable safety profile to other GLP-1 class medications