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However, GDH2 plays an important role in eliminating the growth-inhibiting effect of IDH1 (R132H) mutant gliomas (134)

Tsujii S, Ishisaka M, Shimazawa M, Hashizume T, Hara H

Growth hormone receptor upregulation through the JAK2 pathway further drives fibroblast proliferation, reinforcing the preclinical case for BPC-157 for tendon and ligament recovery

These observations imply the potential of Gclc in safeguarding T-cell survival and function under the cystine-deprived TME

By interpreting the perturbations occurring upon drug treatment at the metabolic pathways level, a more comprehensive understanding of the impact of drugs on the complexity of cells metabolic networks can be achieved