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Interestingly, FOLFOX failed to activate hepatic NF-B or cause liver injury in PAI-1 KO mice

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Because of its antioxidant properties, it may also reduce effectiveness of chemotherapy and radiation therapy (13)

3.7.2 Neuroactive substances produced by the microbiota In addition to participating in the synthesis and regulation of neurotransmitters, the gut microbiota can directly produce various neuroactive substances, such as neuropeptides and neurotransmitter analogs (Hamamah and Covasa, 2022)

Occasionally, similar cells may be seen in the underlying dermis (Figure 5.13), indicating invasion

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