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Both high and low plasma concentrations of betaine are linked to diseases [37]

La Vecchia S, Sebastin C

Glutathione also plays a role in inflammation as the ratio between oxidized and reduced glutathione in the body is indicative of not only overall toxicity, but also inflammatory response

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This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development ( - expression and promoting lipid peroxidation, ultimately triggering ferroptosis ( Notably, androgen excess, a hallmark of PCOS, may also contribute to ferroptosis