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The inconsistency likely arises from differences in experimental conditions, such as pH, Cu+/Cu2+ ratio, A isoform, and the presence of reducing agents or cofactors (190)

Missed diagnosis of underlying conditions: Symptoms that go along with low libido crossover with many serious health problems, such as thyroid disease or diabetes

There is a vast amount of evidence that mitochondrial dysfunction occurs after the early cellular events in AD and can contribute to the advancement of further degeneration, but it is often unclear whether mitochondrial dysfunction is indeed just a secondary event or whether it might be involved in primary pathogenesis

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