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Clinically, in patients with renal failure, acute kidney injury, dialysis and other pathological states of renal function deterioration, renal reabsorption function is impaired, resulting in a significantly lower serum free carnitine concentration than that in healthy people [255], and the metabolic profile of acylcarnitine also changes significantly [256]

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Notably, another study reported that C16-carnitine can directly interact with plasma enzymes and tissue plasminogen activator (tPA) to exert antithrombotic effects by increasing the activities of these enzymes [229], implying that LCAC has a complex dual role in cardiovascular health

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Moreover, MDA content and SOD activity in serum were applied to evaluate lipid accumulation