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Although some clinical trials are in progress, due to severe side effects such as those caused by an undesired pharmacological activity, suppression of the innate immune response to viral and bacterial infections, and damage to the central nervous system and liver, 244,245 these drugs remain challenging for a clinical application

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MSG (800 mg/kg), clomiphene citrate (1 mg/kg), and extracts (100 mg/kg) were administered by gavage daily for two weeks

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Ultimately, the optimal reaction conditions employed 10 mol% PhSeBr ( C5 ) in 1,4-dioxane at room temperature in air