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Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank

Tarrio, M

Researchers have also learned that musculoskeletal fatigue can reduce contractile activity and energy reserves in the muscles, which may also lead to stiffness within tendons and ligaments

Lack of definitive outcomes: Many studies focus on surrogate biomarkers (GSH/GSSG, oxidative stress markers) rather than clinically meaningful endpoints