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Ion is involved in ferroptosis through either the induction of a non-enzymatic iron-mediated Fenton reaction or the activation of iron-containing lipid oxygenases, such as CYP450/cytochrome P450 oxygenases and arachidonate lipoxygenase (ALOX) (38,91)

p = 0.046), gamma-glutamyl transferase (GGT

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Human CBS adopts a unique multi-domain structure: an N-terminal haem binding domain (residues 3874), a central PLP-dependent catalytic domain (CD, residues 75382), and a C-terminal regulatory domain (RD, residues 411551) 5,11,12 (Fig