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Similarly, at the mRNA level, an inverse correlation between TIMP gene expression and IOP (r = 0.93)

elegans activates the AMPK-FOXO pathway, resulting in a significant lifespan extension of over 30% in wild-type worms, 94 suggesting the potential anti-aging role of the AMPK pathway in mammals

In a subsequent study, the authors reported an increase in LPO and nitric oxide (NO) levels, together with significant alterations in GSH redox status in the blood of male Wistar albino rats (age 2 months) exposed to drinking-water containing aspartame at a dose of 40 mg/kg bw for 6 weeks (Proki et al., 2015)

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