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NTZ, especially at the higher dose, elicited similar hepatoprotective effects comparable to NAC and 4-PBA, indicating the possible involvement of ER stress modulation in NTZ-elicited hepatoprotective effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 217.Zmb V., Simon-Szab L., Szelnyi P., Kereszturi ., Bnhegyi G., Csala M

Studies using ghr KO mice showed significantly decreased body mass as well as smaller liver and brain mass/size than control mice (250, 310, 314319) and growth delay (250, 254)

However, unfavorable effects of ALDH2*2 allele have been reported in terms of the risk of some diseases such as osteoporosis [25] and neurodegenerative diseases [24, 26, 27]

The acquired mutations were enriched for the mutational signatures (SBS2) and SBS13 that have been attributed to apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) cytidine deaminase activity

We performed this multicenter study with the aim of validating NIAAA clinical criteria for diagnosis in patients with alcohol associated liver disease (ALD)