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As of writing, studies in laboratory animals have not identified significant safety concerns [3, 4]

Any temperature excursion above 8C risks irreversible protein denaturation

Specifically, the researchers suggested that the cleavage of caspase-3 and its substrate called Poly ADP-ribose polymerase (PARP) appeared markedly reduced, by ~43% and ~77% respectively, suggesting that the peptide complex may suppress this cascade of programmed cell death

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