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Understanding the synergy between these biophysical and protein-mediated mechanisms is crucial for the development of the next generation of high-persistence RNA therapeutics and vaccines

Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

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The reason is that the SemPP is difficult to interpret, since children with no spoken language inappropriately score as less severe than those with limited language

Broad compatibility : Works seamlessly with many medications without compromising performance

Leung S, Mattman A, Snyder F, Kassam R, Meneilly G, Nexo E