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However, under stress conditions, modifications of KEAP1 disrupt this interaction, allowing NRF2 to accumulate and translocate into the nucleus

Along with GSTs, some of these enzymes offer additional routes by which ascorbate and, particularly, glutathione can be linked to peroxide metabolism

This restoration of tissue function could also be accompanied by a reduction in the biomarkers associated with cellular aging, suggesting a return toward a more balanced state of cell function

- Passes through the blood-brain barrier - Supports cognitive health & optimal brain function

Jul 2020;16(3):401-407

H.ZennadiR.LeitgebA.et al (2016)