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doi:10.1196/annals.1354.051

2003;53 Suppl 3:S39-47

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4.5.3.2 Principal factors influencing biomarker application Impact of renal functional status : when glomerular filtration rate declines, multiple metabolic intermediates accumulate systemically, including branched-chain amino acids and aromatic amino acid catabolites, rendering differentiation between authentic pathogenic markers and consequences of diminished renal clearance capacity difficult (50, 51)