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Deficiency in mitochondrial complex I enhances NADPH oxidase activity and oxidative stress, leading to glutathione depletion and impaired energy homeostasis [187,188,189]

doi: 10.1111/j.1471-4159.2009.06109.x 55 KurokawaS.BerryM

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In the previous century, the underlined function of TMAO was the stabilization of proteins against various environmental stress factors, including high hydrostatic pressure [73]

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[4] [5] Research has investigated berberine's potential effects on blood glucose control, lipid profiles, and body weight, though it is not licensed as a medicine by the MHRA in the UK and is sold as a food supplement or herbal product with variable quality